Over the counter alternative for prednisone Effexor is the primary antihyperalgesic drug for rheumatoid arthritis (RA), as it has a long history of success in clinical trials. However, studies of patients treated with Effexor and given either placebo or the drug phenylephrine have indicated that, in some cases, higher blood pressure symptoms were noticed in the placebo group and at same time that no clinically measurable adverse effects were noted at these higher blood pressure levels. This type of effect has often been interpreted as an indication of Effexor causing higher blood pressure than Buy prednisolone eye drops online it is likely to cause. In 2009 a team led by Dr. Frank C. Dastoor, of UCLA led an open-label trial of the effects Effexor on RA in adults. They found that, despite a clear therapeutic benefit, the mean blood pressures taken at the baseline assessment were higher in the group assigned placebo than in those the drug (P<0.05), which meant that many of the placebo participants were getting higher blood pressure than would have been expected. (The lower blood pressures seen in the individuals this study were explained by the lack of blood pressure medication in both groups at baseline.) However, they did not observe any clinically significant adverse effects from the drug-placebo difference in blood-pressure readings, which is consistent with prior research. "In a systematic Buy amoxicillin 500mg online review we compared 13 major trials examining the use of Effexor for RA," Dr. Dastoor said in an email to Healthline. "We found that, overall, only half of the trials reported having observed a reduction in RA‐related complications and only one reported the occurrence of worsening blood pressure. Therefore, further research is required to determine whether Effexor reduces blood pressure or triggers further complications." Why does this happen? Most researchers think that the blood-pressure effect of Effexor occurs via both a reduction in vascular resistance as a natural consequence of the medication's effects on peripheral nerves and vascular smooth muscle tissue. "[The medication] has a substantial and rapid effect on arterial resistance, which is the primary determinant of blood pressure," Dr. Dastoor wrote in an email to Healthline. When blood-pressure-dependent vasodilation is reduced by Effexor, blood-pressure readings increase, particularly when the medication is given in morning. According to Dr. Dastoor, this means that Effexor can increase blood-pressure readings because there is no longer an increase in central cerebral vascular resistance. However, this still does not mean that Effexor causes a rise in blood pressure. Indeed, higher readings can also be produced when the level of central cerebral vascular resistance is increased. There are several possibilities for the cause of this blood-pressure "effect," but Dr. Dastoor is most interested in the involvement of endorphins, dopamine-norepinephrine and serotonin-2A receptor sites mentioned in past scientific reports. "The mechanism [by which Effexor] affects blood pressure is not known," he wrote, "but the literature suggests that it appears to inhibit sympathetic nervous activity and increase neuropathic pain." Another theory is that Effexor might reduce blood-pressure responses to stress, but this has not been scientifically verified. "This [coping with pain] could potentially include the actions of morphine or opioids, but no evidence has been presented in support of this concept," wrote Dr. Dastoor in his email to Healthline. Still another possibility, given recent reports showing that the use of opioids, including morphine, can be associated with a risk of adverse effects on the developing brain, is that Effexor might.
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